Your students have heard about CRISPR, now, they can model how this protein can modify DNA. With Making the Cut with CRISPR-Cas9©’s colorful foam pieces and placemat, your students can build an interactive model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA.
- Build a schematic model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual-guide RNA
- Understand how the Cas9 protein binds to a specific sequence of viral double-stranded DNA at a PAM site - and cuts it
- Demonstrate how that cut destroys the viral genome and prevents the infection of bacteria
- Amplify their learning with student handouts and digital materials